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等级大校
威望22
贴子17028
魅力17450
注册时间@2013-08-09
celiawang
等级大校
威望22
贴子17028
魅力17450
注册时间@2013-08-09
Right now, whether or not a lung cancer patient has a KRAS mutation doesn’t change initial treatment decision making. Standard first-line therapy for a patient with KRAS positive lung cancer may be surgery, radiation, chemotherapy, immunotherapy or a combination based on the stage of their cancer. There is now a targeted therapy pill (also called a KRAS inhibitor) for patients with KRAS G12C. If a patient’s cancer stops responding to chemotherapy or immunotherapy (or a combination), they may be able to go on a targeted therapy pill called sotorasib.
From https://www.lung.org/lung-health-diseases/lung-disease-lookup/lung-cancer/symptoms-diagnosis/biomarker-testing/kras
等级大校
威望22
贴子17028
魅力17450
注册时间@2013-08-09
Adagrasib, sotorasib都是kras g12c inhibitor。但是kras exon2不一定就是g12c mutation。其他kras mutation inhibitor还没有上市。kras exon2 mutation是KRAS mutation里最常见的,KRAS又是lung cancer里最常见的。
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