Right now, whether or not a lung cancer patient has a KRAS mutation doesn’t change initial treatment decision making. Standard first-line therapy for a patient with KRAS positive lung cancer may be surgery, radiation, chemotherapy, immunotherapy or a combination based on the stage of their cancer. There is now a targeted therapy pill (also called a KRAS inhibitor) for patients with KRAS G12C. If a patient’s cancer stops responding to chemotherapy or immunotherapy (or a combination), they may be able to go on a targeted therapy pill called sotorasib. From https://www.lung.org/lung-health-diseases/lung-disease-lookup/lung-cancer/symptoms-diagnosis/biomarker-testing/kras